APC is a tumor suppressor commonly mutated in cancer, and normally functions in several different processes including signaling, cell migration, and cell-cell adhesion. A recent paper shows how different sub-cellular localizations of APC have different functions, and are independently regulated. APC can be found in punctuate clusters, associated with microtubules at membrane extensions, or on the lateral membranes, associated with actin and cell-cell contacts. Images show the association of many actin filaments (green) with the lateral localization of APC (red, “L” is top inset), compared to a smaller number of actin filaments found at APC clusters in membrane extensions (“C” inset is bottom).
Reference: Elizabeth S. Harris, and W. James Nelson. Authors’ Molecular Biology of the Cell paper can be found here.
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