March 11, 2010

When chromosomes are not segregated correctly during mitosis, the resulting cells have an abnormal number of chromosomes, a hallmark of many tumors. The above image shows DNA (blue) with a single chromosomal locus tagged (green) in different stages of a cell division with proper chromosome segregation. Image is part of a new paper showing that the p53 tumor suppressor pathway functions to limit human cell growth after chromosome missegregation.

Reference: Sarah L . Thompson and Duane A. Compton, 2010. Originally published in Journal of Cell Biology, doi 10.1083/jcb.200905057. Paper can be found here.

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