Mutations in the genes PINK1 and Parkin lead to a form of Parkinsons disease. Both PINK1 and Parkin function in protecting cells from damaged mitochondria, and a recent study helps clear up how. PINK1 accumulates on damaged mitochondria, which in turn recruits Parkin to trigger their elimination. Image shows Parkin (left) can be recruited to distressed and depolarized mitochondria (middle) in the presence of PINK1. Box on right shows an enlarged overlay of Parkin and miotchondria.
Reference: Derek P. Narendra, Seok Min Jin, Atsushi Tanaka, Der-Fen Suen, Clement A. Gautier, Jie Shen, Mark R. Cookson, Richard J. Youle. Authors’ PLoS Biology paper can be found here.
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