April 1, 2010

Cell migration is a dynamic and highly coordinated process. A recent paper assigned a role for an unconventional myosin, named MYO18A, in cell migration. Images above show colocalization of this actin motor (green), with PAK2 (red), which is part of a complex that regulates the assembly of adhesion sites seen in motile cells. The colocalization is at lamellipodia and membrane ruffles, which are membrane protrusion structures important for cell motility.

Reference: Rae-Mann Hsu, Ming-Hung Tsai, Ya-Ju Hsieh, Ping-Chiang Lyu, and Jau-Song Yu. Authors’ Molecular Biology of the Cell paper can be found here.

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