The actin and microtubule cytoskeletal networks frequently interact together during cellular processes. A recent paper has uncovered an important role for a protein called Short stop, a member of the spectraplakin family of proteins, that serves to crosslink actin and microtubules at the cell periphery. Through this interaction with the actin cytoskeleton, Short stop functions to regulate microtubule organization. Image above shows Short stop (red) along the lengths of microtubules (green) at the cell periphery.
Reference: Derek A. Applewhite, Kyle D. Grode, Darby Keller, Alireza Zadeh, Kevin C. Slep, and Stephen L. Rogers. Authors’ Molecular Biology of the Cell paper can be found here.
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