Cell migration is a complex process that requires major remodeling of the cytoskeleton. A recent paper has demonstrated an important role for an isoform of calponin, an actin-binding protein, in cell motility. This calponin isoform controls cell migration via its association with and regulation of a major signaling cascade. Image above shows the calponin isoform(red) colocalizing with actin(green) in fibroblast cells (DNA is in blue, merged image is on right).
Reference: Sarah Appel, Philip G. Allen, Susanne Vetterkind, Jian-Ping Jin, and Kathleen G. Morgan. Authors’ Molecular Biology of the Cell paper can be found here.