August 30, 2010

Septins make up a large family of proteins that have diverse roles, most notably in cell division. Some septins are found in neuronal tissue, and a recent paper demonstrates a role for one of the septins in neuronal migration. Images show neurons (white) in the developing mouse brain with or without normal levels of Septin 14. Without normal levels of Septin 14 (right), many neurons are not able to migrate to the correct layer of the tissue, compared to control neurons (left).

Reference: Tomoyasu Shinoda, Hidenori Ito, Kaori Sudo, Ikuko Iwamoto, Rika Morishita, and Koh-ichi Nagata. Authors’ Molecular Biology of the Cell paper can be found here.

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