Retinal detachment occurs when the retinal pigment epithelium (RPE) loses its adhesion to the underlying photoreceptors, and is a sight-threatening condition. A recent paper has looked at the role of a protein called CLIC4 in this adhesion, and found decreased retinal adhesion in CLIC4-suppressed RPE cells. Images are of normal (top) and CLIC4-suppressed (bottom) retinal sections, showing the disorganization of the photoreceptors in the outer nuclear layer (ONL) of retinas with CLIC4-suppressed RPE cells.
Reference: Jen-Zen Chuang, Szu-Yi Chou, and Ching-Hwa Sung. Authors’ Molecular Biology of the Cell paper can be found here.